Hippocampal Morphology and Distinguishing Late-Onset From Early-Onset Elderly Depression
نویسندگان
چکیده
منابع مشابه
Hippocampal volume in early onset depression
BACKGROUND Abnormalities in limbic structures have been implicated in major depressive disorder (MDD). Although MDD is as common in adolescence as in adulthood, few studies have examined youth near illness onset in order to determine the possible influence of atypical development on the pathophysiology of this disorder. METHODS Hippocampal volumes were measured in 17 MDD subjects (age = 16.67...
متن کاملReduced hippocampal volumes and memory loss in patients with early- and late-onset depression.
BACKGROUND Hippocampal volume reduction has been reported inconsistently in people with major depression. AIMS To evaluate the interrelationships between hippocampal volumes, memory and key clinical, vascular and genetic risk factors. METHOD Totals of 66 people with depression and 20 control participants underwent magnetic resonance imaging and clinical assessment. Measures of depression se...
متن کاملHippocampal volume change in depression: late- and early-onset illness compared.
BACKGROUND Evidence for structural hippocampal change in depression is limited despite reports of neuronal damage due to hypercortisolaemia and vascular pathology. AIMS To compare hippocampal and white matter structural change in demographically matched controls and participants with early-onset and late-onset depression. METHOD High-resolution volumetric magnetic resonance imaging (MRI) an...
متن کاملA family study of Alzheimer disease and early- and late-onset depression in elderly patients.
BACKGROUND The substantial symptomatic overlap between depression and dementia in old age may be explained by common genetic vulnerability factors. METHODS We investigated this idea by comparing the occurrence of both disorders in first-degree relatives of 78 patients with Alzheimer disease (AD), of 74 with late-onset depression (onset age of > or = 60 years), of 78 with early-onset depressio...
متن کاملDifferences Between Early and Late Onset Adult Depression
BACKGROUND It is unclear, whether age-of-onset identifies subgroups of depression. AIM To assess the clinical presentation of depression with onset in the early adult age (18-30 years) as compared to depression with later onset (31-70 years). METHOD A total number of 301 patients with first episode depression were systematically recruited. Characteristics including psychiatric co-morbidity,...
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ژورنال
عنوان ژورنال: American Journal of Psychiatry
سال: 2008
ISSN: 0002-953X,1535-7228
DOI: 10.1176/appi.ajp.2007.07030506